منابع مشابه
Chromatin Modifications and Their Function
The surface of nucleosomes is studded with a multiplicity of modifications. At least eight different classes have been characterized to date and many different sites have been identified for each class. Operationally, modifications function either by disrupting chromatin contacts or by affecting the recruitment of nonhistone proteins to chromatin. Their presence on histones can dictate the high...
متن کاملEpigenetics in cancer: targeting chromatin modifications.
Posttranslational modifications to histones affect chromatin structure and function resulting in altered gene expression and changes in cell behavior. Aberrant gene expression and altered epigenomic patterns are major features of cancer. Epigenetic changes including histone acetylation, histone methylation, and DNA methylation are now thought to play important roles in the onset and progression...
متن کاملTopical Review on Epigenetics and Chromatin Modifications Epigenetics: Beyond Chromatin Modifications and Complex Genetic Regulation
Chromatin modifications and epigenetics may play important roles in many plant processes, including developmental regulation, responses to environmental stimuli, and local adaptation. Chromatin modifications describe biochemical changes to chromatin state, such as alterations in the specific type or placement of histones, modifications of DNA or histones, or changes in the specific proteins or ...
متن کاملChromatin Modifications Associated With Diabetes and Obesity.
The incidence of obesity across the globe has doubled over the past several decades, leading to escalating rates of diabetes mellitus, cardiovascular disease, and other complications. Given this dramatic rise in disease incidence, understanding the cause of these diseases is therefore of paramount importance. Metabolic diseases, such as obesity and diabetes mellitus, result from a multitude of ...
متن کاملSignaling to Chromatin through Histone Modifications
in Kornberg and Lorch, 1999). In the classical view, first proposed by Kornberg (1974), each nucleosomal unit is formed by wrapping approximately 146 base pairs of DNA around a histone octamer core particle containing one H3-H4 tetramer and two H2A-H2B dimers. The valid-Genetics Box 800733 ity of this model has been confirmed by determining the crystal structures of the histone octamer, As reve...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Chemical Research in Toxicology
سال: 2018
ISSN: 0893-228X,1520-5010
DOI: 10.1021/acs.chemrestox.8b00267